Smoking topography, brand switching, and nicotine delivery: Results from an in vivo study.

Authors Hammond, D., Fong, G. T., Cummings, K. M., & Hyland, A.
Date June 14, 2007
Publication Link Cancer Epidemiology, Biomarkers & Prevention, 14(6), 1370-5.
http://www.ncbi.nlm.nih.gov/pubmed/15941943
Research Category Design
Country
Citation Hammond, D., Fong, G. T., Cummings, K. M., & Hyland, A. (2005). Smoking topography, brand switching, and nicotine delivery: Results from an in vivo study. Cancer Epidemiology, Biomarkers & Prevention, 14(6), 1370-5. Retrieved July 27, 2010, from  http://www.ncbi.nlm.nih.gov/pubmed/15941943.
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Abstract Department of Psychology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1. dhammond@uwaterloo.ca
Abstract
OBJECTIVE: Exposure to toxins in tobacco smoke is influenced by how a cigarette is smoked. Cigarettes have been designed to allow for a range of puffing behavior and to provide different, nonlinear tar and nicotine yields in response to different puffing profiles. However, puffing behavior and its influence upon risk-exposure has yet to be assessed outside the laboratory, in smokers’ natural environment.METHOD: Fifty-nine adult smokers used a portable device to measure smoking topography over the course of three 1-week trials. Participants were asked to smoke their usual “regular yield” brand through the device for trial 1 and again, 6 weeks later, at trial 2. Half the subjects were then randomly assigned to switch to a “low-yield” brand for trial 3.RESULTS: The findings show a high degree of stability in puffing behavior within the same subject over time but considerable variability between smokers. Smokers who were switched to a “low-yield” cigarette increased their total smoke intake per cigarette by 40% (P = 0.007), with no significant change in their salivary cotinine levels. Cigarettes smoked per day and nicotine yield were only weakly associated with salivary cotinine levels; however, salivary cotinine was strongly associated with a composite measure that included cigarettes per day, brand elasticity, and puffing behavior (sr = 0.61, P < 0.001).CONCLUSIONS: These findings provide strong evidence of behavioral compensation to low-yield cigarettes from in vivo measures of smoking behavior. The findings also show the importance of brand elasticity and smoking topography in predicting nicotine uptake and smoke exposure.

Posted on June 14, 2007, in Cummings, K M - Papers, Fong, Geoffrey papers, Hammond, David Papers, Hyland, Andrew Papers, Project design - Research, Recent peer reviewed papers and tagged , , , , , , , . Bookmark the permalink. Comments Off on Smoking topography, brand switching, and nicotine delivery: Results from an in vivo study..

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